Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, posing a major challenge to global public health systems. The multifactorial nature of CVD pathogenesis involves complex interactions between endocrine imbalance, metabolic syndrome, chronic stress, oxidative stress, inflammatory mediators, mitochondrial dysfunction, and genetic predisposition. This study aimed to improve a multifactorial and integral prevention system for cardiovascular diseases based on a valeological and integrative approach.

The findings substantiate the high effectiveness of a multifactorial, integrative valeological prevention model in reducing cardiovascular risk and improving cardiac morphofunctional resilience. This approach provides a scientifically grounded framework for early prevention and may be recommended for integration into national cardiovascular disease prevention and health promotion programs.

cardiovascular diseases; multifactorial prevention; integral approach; valeology; endocrinemetabolic balance; oxidative stress; psychosomatic factors; lifestyle intervention.

Rahmatjonovna, I. N. (2024). Fast foods are the potential of human health. Ethiopian International Journal of Multidisciplinary Research, 11(05), 365-369.

Isaqova, N. (2022). Bolalarning antropometrik ko’rsatkichlarini turli omillarga bog’liqligi. Science and innovation, 1(D8), 1000-1003.

Рахматжоновна, И. Н. Алиментарного ожирение и репродуктивное здоровье женшин в современном аспекте физической реабилитации. O'zbekiston harbiy tibbiyoti, 4(4), 368-370.

Isaqova, N. (2022). Қабзиятнинг болалар антропометрик кўрсаткичларига таъсири. Science and innovation, 1(D8), 888-892.

Isaqova, N. (2024). MICROSCOPIC EXAMINATION OF SPUTUM. Развитие и инновации в науке, 3(6), 63-66.

Исакова, Н., & Усмонова, Г. (2024, June). ЛАБАРАТОРНАЯ ДИАГНОСТИКА ТРИХОМОНИЗА. In международная конференция академических наук (Vol. 3, No. 6, pp. 59-65).

Raxmatjonovna, I. N. (2024). Labaratory diagnostics of trichomonisis disease. Ethiopian International Journal of Multidisciplinary Research, 11(05), 496-499.

Raxmatjonovna, I. N. (2023). The problem of acceleration of children's development (literature review). International Multidisciplinary Journal for Research & Development. Volume10, (12), 160-164.

Исакова, Н., & Усмонова, Г. Кишечный дисбактериоз//Models and methods in modern science.–2024. Т, 3, 106-112.

Raxmatjonovna, I. N. The most pressing problem today is iodine deficiency. World Bulletin of Public Health, 23, 97-100.

Raxmatjonovna, I. N. Anthropometric indicators of children. Scientific Impulse, 1(5), 883-887.

Isakova, N. R. (2021). The effect of constipation due to diseases of the colon on the anthropometric parameters of children. ASIAN JOURNAL OF MULTIDIMENSIONAL RESEARCH, 10(5), 666-669.