This article analyzes the morphofunctional adaptation mechanisms of the liver under hypoxic conditions. Hypoxia leads to significant disturbances in cellular metabolism and energy production, particularly affecting organs with high metabolic activity such as the liver. The study focuses on structural changes in hepatic tissue, metabolic reprogramming of hepatocytes, mitochondrial functional modulation, and activation of hypoxia-responsive regulatory pathways. Special attention is given to the balance between adaptive and pathological processes during oxygen deficiency. Understanding these mechanisms is essential for improving the diagnosis and management of hypoxia-associated liver dysfunction.

Hypoxia; Liver; Morphofunctional adaptation; Hepatocytes; Mitochondria; Metabolic reprogramming; Oxygen deficiency; Pathophysiology.

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