The integration of life skills training into nursing education and practice has emerged as a crucial component in enhancing both nursing competence and patient care. This study explores interactive life skills strategies designed to improve nursing practice and patient outcomes. By employing a combination of simulation exercises, role-playing, and reflective practices, the research aims to equip nurses with essential life skills such as effective communication, emotional intelligence, problem-solving, and stress management. The study evaluates the impact of these interactive strategies on nursing performance and patient satisfaction through a mixed-methods approach, including quantitative assessments and qualitative feedback. Findings suggest that interactive life skills training significantly enhances nurses' ability to manage complex patient interactions, improves their problem-solving capabilities, and fosters a more empathetic approach to patient care. This research underscores the importance of incorporating life skills into nursing curricula and continuous professional development programs to address the evolving demands of the healthcare environment and improve overall patient outcomes.