Bronchial asthma is a common chronic inflammatory disease of the airways characterized by bronchial hyperreactivity. Data have been obtained on the role of vitamin D deficiency in the pathogenesis of this disease. A genomic association between vitamin D and asthma has been established. Vitamin D exerts anti-inflammatory and immunomodulatory effects. In pregnant women with insufficient intake of antioxidants and vitamins D and E, there is a high risk of giving birth to children with Atopic dermatitis and bronchial asthma. The administration of vitamin D to children helps reduce respiratory diseases and alleviate the course of asthma.

vitamin D, bronchial asthma, pathogenesis, disease course, supplementation, bronchial obstruction

Stauberger E., Myers J. Epidemiology of asthma and allergic diseases. In: Burks W., Holgate S., O'Hehir R., et al., editors. Middleton's Allergy: Principles and Practice, 9th ed. 2020. pp. 713–744.e1.

Asthma. In: Marcdante K., Kliegman R., editors. Nelson Essentials of Pediatrics, 8th ed. 2020. pp. 313–322.

Budchanov Y.I., Delyagin V.M. Genetics of bronchial asthma. Practical Medicine. 2010; No. 6(45): 19–21.

Delyagin V.M., Arakcheeva E.E., Urazbagambetov A., Budchanov Y.I. Genetics of bronchial asthma and atopy. Medical Council. 2012; No. 5: 33–39.

Hejazi M., Chazani-Modaressi F., Enterazi-Maleki T. A review of vitamin D effects on common respiratory diseases: asthma, chronic obstructive pulmonary disease, and tuberculosis. Journal of Research in Pharmacy Practice. 2016; 5(1): 7–15.

Deveruex G., Craig L., Seaton A., Turner S. Maternal vitamin D and E intakes in pregnancy and asthma to age 15 years: a cohort study. Pediatric Pulmonology. 2019; 54(1): 11–19.

Chiu C., Huang S., Peng Y., et al. Maternal vitamin D levels are inversely related to allergic sensitization and atopic diseases in early childhood. Pediatric Allergy and Immunology. 2015; 26(4): 337–343.

Leung T., Wang S., Tang M., et al. Childhood asthma and spirometric indices are associated with polymorphic markers of two vitamin D 25-hydroxylase genes. Pediatric Allergy and Immunology. 2015; 26(4): 375–382.

Pfeffer P., Hawrylowicz C. Vitamin D in asthma. Chest. 2018; 153(5): 1229–1239.

Cannell J., Vieth R., Umhau J., et al. Epidemic influenza and vitamin D. Epidemiology and Infection. 2006; 134(6): 1129–1140.

Litonjua A., Weiss S. Is vitamin D deficiency to blame for the asthma epidemic? Journal of Allergy and Clinical Immunology. 2007; 120(5): 1031–1035.

Masoli M., Fabian D., Holt S., Beasley R.; Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004; 59(5): 469–478.