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BOTULISM PATHOGENESIS AND MECHANISM OF ACTION OF THE TOXIN

Jurayeva Muxabbat Ergashevna , Almardanova Zulhumor Jalilovna , Assistant of the Department of Microbiology, Public Health, Hygiene and Management, TTA Termez Branch, Assistant of the Department of Microbiology, Public Health, Hygiene and Management, TTA Termez Branch.

Abstract

Botulism is one of the acute infectious diseases that develops as a result of the action of a strong neurotoxin on the human body, which is dangerous for life. The etiological factor of this disease is the bacterium Clostridium botulinum. These microorganisms develop in anaerobic conditions and produce a very strong biological poison - botulotoxin. This toxin is recognized in modern biology and medicine as one of the most powerful toxic substances, and even a very small amount of it poses a serious threat to human life.

The pathogenesis of botulism is a complex and multi-stage process, in which the toxin enters the body, spreads and selectively affects the nervous system. The toxin often enters the body through improperly prepared or stored food products. In particular, canned food prepared at home is considered the main source of botulism. The toxin, which has entered the gastrointestinal tract, is quickly absorbed into the bloodstream and begins to exert its effects through the peripheral nervous system.

Keywords

Brucellosis, Brucella, zoonotic infection, Brucella, pathogenesis, epidemiology, immune response, diagnostics, antibiotic therapy, chronic infection, prevention, veterinary control, sources of infection, serological tests, incubation period, occupational hazard

References

World Health Organization. Botulism: Fact Sheet. Geneva, 2023.

Centers for Disease Control and Prevention. Botulism Guidelines and Prevention Strategies. Atlanta, 2022.

Murray P.R., Rosenthal K.S., Pfaller M.A. Medical Microbiology. Elsevier, 2021.

Brooks G.F., Carroll K.C., Butel J.S. Jawetz, Melnick & Adelberg’s Medical Microbiology. McGraw-Hill, 2022.

Sobirov A., Karimov Sh. Infectious diseases. Tashkent, 2020.

Shapiro R.L., Hatheway C., Swerdlow D.L. Botulism in the United States: epidemiology and clinical features. Annals of Internal Medicine, 2018.

Simpson L.L. The origin, structure, and pharmacological activity of botulinum toxin. Pharmacological Reviews, 2019.

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BOTULISM PATHOGENESIS AND MECHANISM OF ACTION OF THE TOXIN. (2026). International Journal of Artificial Intelligence, 6(4), 3-10. https://www.academicpublishers.org/journals/index.php/ijai/article/view/12101