Superficial vein thrombosis (SVT) of the lower extremities remains a clinically relevant condition due to its risk of thromboembolic complications and variability in response to anticoagulant therapy. The aim of this study was to evaluate the clinical and ultrasound effectiveness of anticoagulant therapy and to identify factors influencing thrombus regression. A prospective observational study included 104 patients with acute SVT associated with varicose vein disease who received anticoagulant therapy with dynamic clinical and duplex ultrasound monitoring over 8 weeks. Clinical improvement was observed in 87.5% of patients and was accompanied by thrombus disorganization, decreased echogenicity, and, in some cases, partial recanalization. Two patterns of response were identified: rapid regression (27.9%) and delayed regression (72.1%), associated with the severity of inflammatory changes, thrombus structure, and early presentation. The effectiveness of anticoagulant therapy was also influenced by local hemodynamic conditions. These findings highlight the importance of combined clinical and ultrasound assessment for predicting treatment outcomes.

superficial vein thrombosis; anticoagulant therapy; varicose veins; duplex ultrasonography; thrombus morphology; thrombus regression; venous thrombosis; inflammation; periphlebitis; hemodynamics; low-molecular-weight heparin; recanalization.

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