Herbal-based ointments and creams have gained significant attention in the global pharmaceutical and cosmetic industries due to their natural origin, therapeutic potential, and favorable safety profile. The increasing demand for phytopharmaceutical and cosmeceutical products has stimulated the development of advanced manufacturing technologies and quality control systems. This paper discusses the major global features of herbal ointment and cream production, including the use of standardized plant raw materials, implementation of Good Manufacturing Practice (GMP) and Good Agricultural and Collection Practice (GACP) standards, and the application of environmentally sustainable “green” technologies. Special attention is given to modern biotechnological approaches, including plant cell culture technologies, nanoemulsions, liposomes, phytosomes, and controlled-release delivery systems, which improve the stability, bioavailability, and therapeutic efficacy of herbal formulations. The study also highlights the importance of microbiological safety, analytical standardization, and innovative packaging technologies in ensuring product quality and stability. Furthermore, the rapid development of the cosmeceutical sector and the integration of pharmaceutical and cosmetic sciences are discussed as important trends in the global market. Overall, herbal ointment and cream production continues to evolve toward safer, more effective, and environmentally sustainable formulations with broad applications in dermatology, cosmetology, and regenerative medicine.

Herbal ointments; Herbal creams; Phytopharmaceuticals; Cosmeceuticals; Nanoemulsions; Liposomes; Phytosomes; Green technologies; GMP; GACP; Biotechnological production; Plant extracts; Drug delivery systems; Dermatology; Regenerative medicine.

Ekiert, H., Szopa, A., Kubica, P., et al. Plant cell and tissue cultures: Modern approaches for the production of biologically active compounds. Applied Microbiology and Biotechnology. 2018;102:765–778.

Patel, A., Cholkar, K., Agrahari, V., Mitra, A.K. Ocular drug delivery systems: An overview. World Journal of Pharmacology. 2013;2(2):47–64.

Nohynek, G.J., Dufour, E.K. Nano-sized cosmetic formulations and the skin barrier: A review. Critical Reviews in Toxicology. 2012;42(3):251–264.

Pandey, M.M., Rastogi, S., Rawat, A.K.S. Indian herbal drug for general healthcare: An overview. The Internet Journal of Alternative Medicine. 2013;8(2):1–10.

European Medicines Agency (EMA). Guidelines on Good Agricultural and Collection Practice (GACP) for medicinal plants. London: EMA; 2006.

World Health Organization (WHO). WHO Guidelines on Good Manufacturing Practices (GMP) for Herbal Medicines. Geneva: WHO; 2007.

Souto, E.B., Müller, R.H. Cosmetic features and applications of lipid nanoparticles. International Journal of Cosmetic Science. 2008;30(3):157–165.

Mukherjee, P.K. Quality Control and Evaluation of Herbal Drugs. Amsterdam: Elsevier; 2019.

Dhiman, S., Singh, T.G., Rehni, A.K., et al. Herbal nanocarriers for topical drug delivery: Current advances and future perspectives. Journal of Drug Delivery Science and Technology. 2021;63:102487.

Bonifácio, B.V., Silva, P.B., Ramos, M.A.S., et al. Nanotechnology-based drug delivery systems and herbal medicines: A review. International Journal of Nanomedicine. 2014;9:1–15.