A growing body of experimental evidence has gradually shown that aging and carcinogenesis share many common molecular pathways. During aging, the accumulation of genetic and epigenetic changes, reduction in telomere length, progressive impairment of DNA damage repair mechanisms, regulation of glucose metabolism, cell cycle control, and stem cell self-renewal lead to the induction of senescence or apoptosis and loss of replicative capacity. The same cellular dysfunctional mechanisms that characterize the aging process have been found to be involved, with varying levels of evidence, in carcinogenesis and are discussed herein.

carcinogenesis, aging, apoptosis, inflammation

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GAFFAROV Ganisher Karimovich, ABDIRASHIDOVA Gulnoza Ablakulovna, & Bakiyev Shavkat Sherzodovich. (2024).

TOʻR PARDA KOʻCHISHI PATOFIZIOLOGIYASI. FAN, TA'LIM, MADANIYAT VA INNOVATSIYA JURNALI | JOURNAL OF SCIENCE, EDUCATION, CULTURE AND INNOVATION, 3(5), 231–236.

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