Articles | Open Access |

DIABETES MELLITUS WITH TYPE 2, DIABETIC PERIPHERAL SLEEP DISORDERS IN PATIENTS WHO ARE COMPLICATED BY A PAINFUL FORM OF NEUROPATHY

Topvoldiyev Murodjon , Assisent of the Department of fundamentals of Preventive Medicine

Abstract

This article examined the sleep quality of patients with diabetes mellitus 2 Type (QD 2 Type), which is complicated by the painful form of diabetic polyneuropathy (DPN). 50-80% of patients with chronic pain experience sleep disorders,while the severity of sleep disorders depends on the strength of the pain. Sleep disorders and neuropathic pain are interrelated and should be treated at the same time. One of the factors that affect sleep in order to improve sleep - the treatment of the painful form of DPN leads patients to improve the quality of sleep and, alternatively, the quality of life of them. The relationship between neuropathic pain and sleep disorders is twofold.Neuropathic pain patients develop sleep disorders with large extimol, and these sleep disorders in turn lead to increased pain. A positive relationship has been found between pain sensitivity and sleep disorders. Pain tolerance has been found to decrease in patients with chronic pain and insomnia. In our examination, 120 people received ogrigan patients with 2 types of QD. The duration of QD was 3 to 12 years, with those examined averaging 56.6±9.8 years of age, of which 79 (65.8%) were women and 41 (34.2%)were men. In contrast, the control group received 20 non-QD patients, of whom 5 (25%) had AG, with an average age of 55.9±7.5 years. Patients were classified into two groups with sleep quality disorders and no sleep quality disorders.

100% of patients with QD type 2, complicated by the painful form of DPN, were found to have varying levels of sleep quality disorders. In this case, the most reported complaints of patients in Group 1 were “feeling of post-waking fatigue from night sleep”, this complaint was reported by 100% of patients, while only 45% of patients in Group 2 accounted for patients. Other complaints that determined the quality of sleep in patients also dominated Group 1 patients. This in turn reaffirmed that the painful form of DPN QD 2 has an effect on the quality of sleep of different patients.

Keywords

Diabetes Mellitus Type 2, diabetic neuropathy, peripheral neuropathy,neuropathic pain, sleep disorders, sleep quality, neuropathy and pain, pain and sleep.

References

Almoznino G, Benoliel R, Sharav Y, Haviv Y. Sleep disorders and chronic craniofacial pain: characteristics and management possibilities. [Текст] / 1. Almoznino G, Benoliel R,Sharav Y, Haviv Y. // Sleep Med Rev. — 2017. — № . — С. 39-50.

Argoff CE. The coexistence of neuropathic pain, sleep, and psychiatric disorders: anovel treatment approach. [Текст] / Argoff CE. // Clin J Pain. — 2007. — № 23(1). — С.15-22.

Attal N, Cruccu G, Baron R, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. [Текст] / Attal N, Cruccu G, Baron R, et al. // Eur J.Neurol. . — 2010. — № 17(9). — С. 1113-e88.

Bari§ N., Erdogan M., Sezer E., Saygili F., MertOzgönül A., Turgan N., Ersöz B.

Alterations in L-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuria [Текст] / Bari§ N., Erdogan M., Sezer E., Saygili F., MertOzgönül A., Turgan N., Ersöz B. // ActaDiabetol. — 2009. — № 46(4). — С. 309-316.

Benoliel R, Eliav E, Sharav Y. Self-reports of pain-related awakenings in persistent orofacial pain patients. JOrofac Pain. 2009;23(4):330–8.

Boyle, J. P., Thompson, T. J., Gregg, E. W., Barker, L. E. & Williamson, D. F.

Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. [Текст] / Boyle, J. P., Thompson, T. J.,Gregg, E. W., Barker, L. E. & Williamson, D. F. // Popul. Health Metr.. — 2010. — № 8. —С. 29.

N. Çakici, T.M. Fakkel, J.W. van Neck, A.P. Verhagen, J.H. Coert Systematic review of treatments for diabetik peripheral neuropathy [Текст] / N. Çakici, T.M. Fakkel, J.W. van Neck, A.P. Verhagen, J.H. Coert // Diabet Med. . — 2016. — № 33(11) . — С. 1466-1476.

Callaghan, B. C., Price, R. S., Chen, K. S. & Feldman, E. L. The importance of raresubtypes in diagnosis and treatment of peripheral neuropathy: a review. [Текст] / Callaghan,B. C., Price, R. S., Chen, K. S. & Feldman, E. L. // JAMA Neurol. . — 2015. — № 72. — С.1510–1518.

Cheatle MD, Foster S, Pinkett A, Lesneski M, Qu D, Dhingra L. Assessing and

managing sleep disturbance in patients with chronic pain. [Текст] / Cheatle MD, Foster S,Pinkett A, Lesneski M, Qu D, Dhingra L. // AnesthesiolClin.. — 2016. — № 34(2). — С.379–93.

D’Angelo R, Morreale A, Donadio V, et al. Neuropathic pain following spinal cordinjury: what we know about mechanisms, assessment and management. [Текст] / D’Angelo R, Morreale A, Donadio V, et al. // Eur Rev Med Pharmacol Sci.. — 2013. — № 17(23). —С. 3257–61.

Devor M, Wood I, Sharav Y, Zakrzewska JM. Trigeminal neuralgia during sleep.

[Текст] / Devor M, Wood I, Sharav Y, Zakrzewska JM. // Pain Pract.. — 2008. — № 8(4).— С. 263–8.

Fan H, Yu W, Zhang Q, et al. Efficacy and safety of gabapentin 1800 mg treatment for post-herpetic neuralgia: a meta-analysis of randomized controlled trials [Текст] / Fan H, YuW, Zhang Q, et al. // J Clin Pharm Ther.. — 2014. — № 39(4). — С. 334–42.

Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. [Текст] / Finnerup NB, Attal N, Haroutounian S, et al. // Lancet Neurol.. — 2015. — № 14(2). — С. 162–73.

Freynhagen R, Grond S, Schupfer G, et al. Efficacy and safety of pregabalin in

treatment refractory patients with various neuropathic pain entities in clinical routine. [Текст]/ Freynhagen R, Grond S, Schupfer G, et al. // Int J ClinPract.. — 2007. — № 61(12). — С.1989–96.

Colten HR, Altevogt BM,. Sleep disorders and sleep deprivation: an unmet public health problem. / Colten HR, Altevogt BM,. [Текст] // Sleep physiology.. — Washington,DC: The National Academies Press; :Institute of Medicine (US) Committee on Sleep Medicine and Research., . — С. .

Jennifer Zitser, Isabel Elaine Allen, Neus Falgàs, Michael M Le , Thomas C Neylan,Joel H Kramer, Christine M Walsh. Pittsburgh Sleep Quality Index (PSQI) responses are modulated by total sleep time and wake after sleep onset in healthy older adults. [Текст] /Jennifer Zitser, Isabel Elaine Allen, Neus Falgàs, Michael M Le , Thomas C Neylan, Joel H Kramer, Christine M Walsh. // Int J ClinPract.. — 2022 Jun 24. — № 17(6). — С. :e0270095.doi: 10.1371/journal.pone.0270095. eCollection 2022.

Lampl C, Schweiger C, Haider B, Lechner A. Pregabalin as mono- or add-on therapy for patients with refractory chronic neuropathic pain: a post-marketing prescription-event monitoring study. [Текст] / Lampl C, Schweiger C, Haider B, Lechner A. // J Neurol.. —2010. — № 257(8). — С. 1265–73.

Markman JD, Jensen TS, Semel D, et al. Effects of pregabalin in patients with

neuropathic pain previously treated with gabapentin: a pooled analysis of parallel-group,randomized, placebo-controlled clinical trials. [Текст] / Markman JD, Jensen TS, Semel D, etal. // Pain Pract.. — 2017. — № 17(6). — С. 718–28.

Roth T, van Seventer R, Murphy TK. The effect of pregabalin on pain-related sleepinterference in diabetik peripheral neuropathy or postherpetic neuralgia: a review of nine clinical trials. [Текст] / Roth T, van Seventer R, Murphy TK. // Curr Med Res Opin.. —2010. — № 26(10). — С. 2411–9.

WHO World Health Organization. Diabetes. / WHO [Электронный ресурс] //

www.who.int : [сайт]. — URL: https://www.who.int/news-room/fact-sheets/detail/diabetes(2018). (дата обращения: 27.09.2023).

WHO World Health Organization. Diabetes. / WHO [Электронный ресурс] //www.who.int : [сайт]. — URL: https://www.who.int/news-room/fact-sheets/detail/diabetes(2018).

IDF(2021 г.). Диабетический атлас IDF - 11-е издание: основные положения. /IDF(2021 г.). [Электронный ресурс] // https://diabetesatlas. org : [сайт]. — URL:https://diabetesatlas. org/key-messages. html (дата обращения: 27.09.2023).

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DIABETES MELLITUS WITH TYPE 2, DIABETIC PERIPHERAL SLEEP DISORDERS IN PATIENTS WHO ARE COMPLICATED BY A PAINFUL FORM OF NEUROPATHY. (2024). International Journal of Artificial Intelligence, 4(08), 79-82. https://www.academicpublishers.org/journals/index.php/ijai/article/view/1399