Post-COVID viral etiology pancreatitis has emerged as a significant clinical concern in recent years. This article analyzes cases of pancreatitis associated with COVID-19 and other viral pathogens such as CMV, EBV, and hepatitis viruses, focusing on clinical presentation, diagnostic challenges, and therapeutic strategies. A comprehensive literature review was performed utilizing the latest scientific publications, clinical case studies, and international treatment guidelines. Results indicate that pancreatitis in COVID-19 patients may present atypically or with a delay, complicating the diagnostic process despite advancements in laboratory and imaging modalities. Treatment is primarily symptomatic, antiviral when indicated, and often minimally invasive. The study concludes that due to its complex presentation and potentially severe course, viral pancreatitis should remain a focus for clinicians, particularly in the post-COVID era, to improve timely diagnosis and patient outcomes.

COVID-19, viral pancreatitis, diagnostics, CMV, EBV, hepatitis viruses, ACE2, treatment challenges

Dirweesh, A., et al. (2021). Clinical characteristics of COVID-19–associated pancreatitis. Pancreatology, 21(3), 615–620.

Liu, F., et al. (2020). ACE2 expression in pancreas may cause pancreatic damage after SARS-CoV-2 infection. Clinical Gastroenterology and Hepatology, 18(9), 2128–2130.

Mao, R., et al. (2020). Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis. The Lancet Gastroenterology & Hepatology, 5(7), 667–678.

McNabb-Baltar, J., et al. (2020). Lipase elevation in patients with COVID-19. The American Journal of Gastroenterology, 115(8), 1286–1288.

Tenner, S., et al. (2013). American College of Gastroenterology guideline: management of acute pancreatitis. The American Journal of Gastroenterology, 108(9), 1400–1415.

Wang, F., et al. (2020). Pancreatic injury patterns in patients with coronavirus disease 19 pneumonia. Gastroenterology, 159(1), 367–370.