Experiments were performed on white, outbred rats of different ages (15 days, 1 month, 2 months, 3 months and 4 months). After reaching a certain age, they were decapitated under anesthesia and their pancreas was removed.

During decapitation, blood was collected. Amylolytic and lipolytic activity was determined in the filtrate and blood serum, the activity of these enzymes was studied in postnatal ontogeny in the pancreas and blood. Amylase and lipase enzymes were fully formed in the pancreas of rats at the age of 4 months, and in the blood at 3-4 months of age. These changes in the amylolytic and lipolytic activities in the pancreatic tissue and blood of rats depend on the change in their feeding pattern (transition from lactotroph to mixed diet), increased energy expenditure, and changes in the enteropancreatic recirculation of these enzymes.

The pancreas, enzyme, homeostasis, postnatal ontogeny.

Aliev A.A. Lymph and lymphobrashchenie u produktovykh jivotnykh.-L.: Nauka. - 1982. -288p.

Blagovidov D.F., Sarkisov D.S. Compensatory processes after resection of the pancreas. - M.: Medicine, 1976.-136p.

Gubergritz N.B. Practical pancreatology. Donetsk. 2008. 318 p.

Korotko G.F., Kovalenko O.K. Hydrolysis of lymph and incretion of pancreatic enzymes // Physiol. Journal. USSR - 1978. - T.63, No. 11. -S.41-49.

Korotko G.F. Fermenty pishchevaritelnykh zhele v krovi (essay on enzyme homeostasis). Tashkent: Medicine. 1983. 212 p.

Korotko G.F. Secretion podjeludochnoy signs. 2nd dop. Izd. Krasnodapr: Izd. KGMU. 2005. 256p.

Korotko G,F. Secretion slyunnyx izlej i elementi salivodiagnostikei. M.: ID Academy Estestvoznania. 2006,192 p.

Korotko G.F. Recirculation fermentov pishchevaritelnyx indicated. - Krasnodar. 2011. 143p.

Makarova T.M., Voskanyan S.E., Korotko G.F., Sapin M.R. Morphofunctional determinants of vnutriprotokovy regulation of salivary and subventricular secretions. Quick. doc. Vseros. Nauchno-prakticheskoy conference "Physiological science - clinical gastroenterology", Essentuki, 2001.- P.83.

Permyakov N.K., Podolsky A.E., Titova G.P. Ultrastructural analysis of the secretory cycle of the pituitary gland. - M.: Medicine, 1973. - 238p.

Pulatov A.S. Secretsiya i recretsiya fermentov tonkoy kishki i rol v ee deyatelnosti inkretiruemoy amilazy. Autoref. Diss. Doc. Med. Nauk. - Kazan, 1978. 26p.

Ransberger K., Noy S. Enzyme and enzyme therapy. Munich. Med. Obshch. Izuch. Enzymov. 1994. – 243 p.

Shechtman M.M., Korotko G.F., Burkov S.G. Physiology and pathology of organ pishchevarenia and iberemennyx. - Tashkent: Medicine, 1989. - 160 p.

Gorelick FS, Jamieson JD. Structure-function relationship of the Pancreas. In: Physiol. Of the gastrointestinal tract (Sec. ed.). Raven-Press-New York. - 1986. - Vol. 2. – P. 1089-1108..

Hara H., Narakino H. Enhancement of pancreatic secretion by dietary protein in rats with chronic diversion of bile-pancreatic juice from the proximal small intestine // Pancreas.-1994. - Vol. 9. -No. 2. -P. 275-279.

Miyasaka K., Nakamura R., Funakoshi A. et al. Stimulatory effect of monitor peptide and human pancreatic secretory trypsin inhibitor on pancreatic secretion and cholecystokinin release in conscious rats // Pancreas/ -1989. Vol. 4. No. 2. - P. 139-144.

Rothman S.S. Passage of proteins through membranes old assumptions and new perspectives // Am. J. Physiol. - 1980. - V. 238. - P. 391-402.

Varro V. On the value of plasma and urinary pepsinogen determinations // J. Indian Med.Profess. - 1965. Vol. 12. No. 8. -P. 5533-5539.