
STUDY OF THE REACTIONS OF ETHYL CHLOROHYDRIN AND MONOCHLOROACETIC ACID ETHYL ESTER WITH SOME TERTIARY AMINES
GULOVA MAFTUNA,BAXTIYOR BO‘RIXONOV,ARZIQUL PANJIYEV,BOXODIR SHAODMONOV , Karshi State Technical UniversityAbstract
A quaternary ammonium salt was synthesized based on ethylene chlorohydrin. Alternative reaction conditions were studied to optimize the synthesis process. The resulting quaternary ammonium salt was subsequently reacted with chitosan. Given the inherently high biological activity of chitosan, its conversion into a quaternized, positively charged form was found to further enhance its bioactivity. The synthesized compounds were analyzed using physicochemical methods, including IR and ¹H NMR spectroscopy. The obtained data confirmed the successful formation of the quaternary ammonium chitosan derivative.
Keywords
Ethylene chlorohydrin, Chitosan, DMF, Ethanol, Choline, Trabectedin, Solifenacin, Noscapine, Quinapril, IR spectrum, ¹H NMR spectrum.
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