Articles
| Open Access | HYPOKINESIA AS A FACTOR IN IMPAIRED TISSUE REGENERATION IN THE SMALL INTESTINE: MORPHOMETRIC AND HISTOLOGICAL DATA
Mukhammadjanova S.A., Akbarova B.B. , Assistant Kokand University Of Andijan BranchAbstract
Hypokinesia, as a form of motor deprivation, is one of the relevant stress factors affecting the morphofunctional state of the digestive system. This article presents the results of an experimental study aimed at assessing the impact of hypokinesia on tissue regeneration of the duodenal mucosa in laboratory animals. Morphometric and histological analysis revealed significant alterations in the crypt-villus architecture, including reduced villus height, disturbed ratio between goblet and enterocyte cells, and decreased epithelial proliferative activity. A phase of partial compensation was identified during the first 30 days of hypokinesia, followed by depletion of adaptive mechanisms at later stages. The obtained data confirm that hypokinesia significantly impairs the regenerative potential of the intestinal epithelium, which may underlie functional digestive disorders associated with a sedentary lifestyle.
Keywords
hypokinesia, tissue regeneration, small intestine, duodenum, morphometry, histology, goblet cells, crypt-villus complex, adaptation, physical activity.
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