Articles | Open Access |

GENETIC ENGINEERING AND BIOTECHNOLOGY: MODERN APPLICATIONS IN MEDICINE

Kuriyazova Saodat Matkarimovna , Muzaparov Azizbek Ulugbekovich, Isoqov Abduxalim Shamsiddinovich , Tashkent State Medical University

Abstract

Genetik engineering and biotechnology represent transformative forces in modern medicine, reshaping diagnostics, therapeutics, and preventive care. This article explores key advancements, including CRISPR-Cas9 genome editing, gene therapy for inherited disorders, and the biotechnological development of mRNA vaccines. It also examines the integration of personalized medicine, stem cell technologies, and molecular biology in clinical practice. While these innovations hold immense promise, they also raise significant ethical, legal, and social concerns. The article highlights both the opportunities and challenges of genetic engineering in healthcare and concludes with a perspective on future directions in this rapidly evolving field.

Keywords

Genetik engineering, Biotechnology, Gene therapy, CRISPR-Cas9, Personalized medicine, Molekular biology.

References

Duodna, J. A., & Charpentier, E. (2020). The new frontier of genome engineering with CRISPR-Cas9. Science, 368(6491), 36-44.

Meader, M. L., & Gersbach, C. A. (2016). Genome-editing technologies for gene and cell therapy. Molecular Therapy, 24(3), 430-446.

High, K. A., & Roncarolo, M. G. (2019). Gene therapy. New England Journal of Medicine, 381(5), 455-464.

Jackson, N. A., Kester, K. E., Casimiro, D., Gurunathan, S., & DeRosa, F. (2020). The promise of mRNA vaccines: a biotechnology platform for the future. Vaccine, 38(14), 2136-2145.

June, C. H., O'Connor, R. S., Kawalekar, O. U., Ghassemi, S., & Milone, M. C. (2018). CAR T cell immunotherapy for human cancer. Science, 359(6382), 1361-1365.

Li, C., & Samulski, R. J. (2020). Engineering adeno-associated virus vectors for gene therapy. Nature Reviews Genetics, 21(4), 255-272.

Mullard, A. (2020). FDA approves landmark gene therapy for SMA. Nature Reviews Drug Discovery, 19(7), 435-436.

Cyranoski, D. (2019). The CRISPR-baby scandal: what’s next for human gene-editing. Nature, 566(7745), 440-444.

Roth, T. L., Puig-Saus, C., Yu, R., & Ribas, A. (2019). Engineering T cells for cancer therapy. Current Opinion in Immunology, 59, 20-25.

Wang, D., Tai, P. W. L., & Gao, G. (2019). Adeno-associated virus vector as a platform for gene therapy delivery. Nature Reviews Drug Discovery, 18(5), 358-378.

Zhang, X. H., Tee, L. Y., Wang, X. G., Huang, Q. S., & Yang, S. H. (2015). Off-target effects in CRISPR/Cas9-mediated genome engineering. Molecular Therapy - Nucleic Acids, 4, e264.

Ledford, H. (2022). mRNA vaccines herald new era for genetic medicine. Nature, 602(7895), 20-22.

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GENETIC ENGINEERING AND BIOTECHNOLOGY: MODERN APPLICATIONS IN MEDICINE. (2025). International Journal of Artificial Intelligence, 5(10), 795-797. https://www.academicpublishers.org/journals/index.php/ijai/article/view/6929