Articles | Open Access |

THE IMPACT OF STRESS ON WOMEN'S REPRODUCTIVE HEALTH AND ITS CLINICAL SIGNIFICANCE

Valijonov Shukurullo Salimjon ugli, Ahmadaliyeva Oqila Umidjon kizi , Kokand University, Andijan Branch, Faculty of Medicine

Abstract

This article provides a comprehensive analysis of the effects of stress on women’s reproductive health and its clinical significance. Reproductive health is a state that reflects the harmonious functioning of hormonal, physiological, and psychological balance in a woman’s body, directly determining her fertility potential. Research shows that chronic stress suppresses the activity of the hypothalamic–pituitary–ovarian (HPO) axis, reduces the secretion of gonadotropic hormones (FSH, LH), and consequently leads to ovulation disorders, menstrual irregularities or amenorrhea, infertility, polycystic ovary syndrome (PCOS), and endometriosis. Furthermore, during stress, the levels of cortisol and prolactin increase, disrupting the balance of estrogen and progesterone, which exacerbates reproductive dysfunctions. The article examines in detail the physiological, hormonal, and psychological mechanisms of stress, their effects on the female body, and approaches to reducing stress and restoring reproductive health through psychological, medical, and lifestyle-based interventions. In conclusion, it is emphasized that controlling stress and creating a mentally healthy environment are key preventive factors in maintaining women’s reproductive health.

Keywords

Stress, women’s reproductive health, hormonal balance, hypothalamic–pituitary–ovarian axis, cortisol, infertility, menstrual irregularities, endocrine system, psychological factors, reproductive dysfunction.

References

Li, J., Chen, Y., Zhang, X. Impact of stress on oocyte quality and reproductive outcome. Journal of Biomedical Science, 2016; 23(1): 1–8.

Rooney, K. L., Domar, A. D. Lifestyle and fertility: the influence of stress and quality of life on female fertility. Reproductive Biology and Endocrinology, 2018; 16(1): 113.

Fedotova, J., Arsenijevic, N., Bivol, S. The effect of stress on the female reproductive system: pathophysiology and neuroendocrine interactions. Obstetrics and Gynecology Reports, 2023; 9(2): 45–57.

Sliwowska, J. H., Kalra, S. P., Kalra, P. S. Linking stress and infertility: a novel role for ghrelin. Endocrine Reviews, 2020; 41(2): 432–446.

Kang, H., Park, E., Lee, S. The effect of job stress on fertility, its intention, and infertility treatment among the workers: a systematic review. BMC Public Health, 2025; 25(1): 21790.

Wang, L., Zhang, H., Liu, M. Influence of perceived stress on fertility intention among women of childbearing age without children: multiple mediating effect of anxiety, family communication and subjective well-being. Reproductive Health Journal, 2024; 21(3): 1855.

Vnuk, I., Petrenko, O., Hrytsenko, A. Effect of stress on ovulatory function. Reports of Vinnytsia National Medical University, 2023; 27(1): 78–83.

Sharma, R., Biedenharn, K. R., Fedor, J. M., Agarwal, A. Lifestyle factors and reproductive health: taking control of your fertility. Reproductive Biology and Endocrinology, 2013; 11(66): 1–10.

Nepomnaschy, P. A., Flinn, M. V. Stress and female reproduction: evolutionary perspectives on mechanisms and functions. Human Nature, 2009; 20(2): 124–149.

Li, X., Xu, J., Zhou, Y. Stress, reproductive hormones, and menstrual disorders: a review of mechanisms and implications. Frontiers in Endocrinology, 2022; 13: 915204.

Article Statistics

Downloads

Download data is not yet available.

Copyright License

Download Citations

How to Cite

THE IMPACT OF STRESS ON WOMEN’S REPRODUCTIVE HEALTH AND ITS CLINICAL SIGNIFICANCE. (2025). International Journal of Artificial Intelligence, 5(10), 1550-1556. https://www.academicpublishers.org/journals/index.php/ijai/article/view/7174