This study, titled "Unraveling Genomic Clinic Dynamics: Navigating Uncertainty Through Reflexive Standardization," delves into the intricate dynamics of genomic clinics and explores the efficacy of reflexive standardization as a strategic approach in mitigating uncertainty. In the evolving landscape of genomics within healthcare, the complexity associated with interpreting genomic data introduces challenges that necessitate novel methodologies. This research employs a mixed-methods approach, combining qualitative insights and quantitative analysis, to unravel the current state of genomic clinic practices and examine the impact of reflexive standardization on addressing uncertainty. The findings contribute valuable insights to the field of genomics, shedding light on potential enhancements in clinical decision-making and patient care.

Genomic Clinics, Genomic Data Interpretation, Uncertainty Management

Abraham J. (1993). Scientific standards and institutional interests: Carcinogenic risk assessment of Benoxaprofen in the UK and US. Social Studies of Science, 23(3), 387–444.

Bahcall O. (2016). ExAC boosts clinical variant interpretation in rare diseases. Nature Reviews Genetics, 17, 584.

Castel P. (2009). What’s behind a guideline? Authority, competition and collaboration in the French oncology sector. Social Studies of Science, 39(5), 743–764.

Cheon J. Y., Mozersky J., Cook-Deegan R. (2014). Variants of uncertain significance in BRCA: A harbinger of ethical and policy issues to come? Genetics in Medicine, 6, 121.

Davies S. C. (2017). Generation genome: Annual report of the chief medical officer 2016. Department of Health.

Domchek S., Weber B. L. (2008). Genetic variants of uncertain significance: Flies in the ointment. Journal of Clinical Oncology, 26(1), 16–17.

Federici G., Soddu S. (2020). Variants of uncertain significance in the era of high-throughput genome sequencing: A lesson from breast and ovary cancers. Journal of Experimental & Clinical Cancer Research, 39, 46.

Feero W. G. (2014). Clinical application of whole-genome sequencing: Proceed with care. Journal of the American Medical Association, 311, 1017–1019.

Halverson C. M. E. (2019). Standards and legacies: Pragmatic constraints on a uniform gene nomenclature. Social Studies of Science, 49(3), 432–455.