This study investigates the potential efficacy of a pineapple and ginger elixir in alleviating primary dysmenorrhea pain among adolescents. Primary dysmenorrhea, characterized by painful menstrual cramps, is a common gynecological condition affecting young women. Pineapple and ginger have been traditionally used for their anti-inflammatory and analgesic properties. In this randomized controlled trial, adolescent participants experiencing primary dysmenorrhea were administered either a pineapple and ginger drink or a placebo. Pain intensity and duration were assessed before and after intervention using standardized pain scales. Preliminary findings suggest that the pineapple and ginger elixir may offer significant relief from primary dysmenorrhea pain compared to the placebo. Further research is warranted to validate these results and explore the underlying mechanisms of action.

Glutathione, often hailed as the master antioxidant, plays a pivotal role in maintaining cellular health and protecting against oxidative stress. This review delves into the multifaceted functions of glutathione, exploring its intricate mechanisms of action and its profound impact on health and disease. Through its ability to neutralize free radicals and detoxify harmful substances, glutathione serves as a crucial defender against oxidative damage and inflammation. Moreover, glutathione's involvement in various physiological processes, including immune function, DNA repair, and protein synthesis, underscores its significance in maintaining overall well-being. Dysregulation of glutathione levels has been implicated in numerous pathological conditions, ranging from neurodegenerative diseases to cancer and aging-related disorders. Understanding the intricate interplay between glutathione and cellular homeostasis offers insights into potential therapeutic strategies for combating oxidative stress-related ailments. This review synthesizes current knowledge on glutathione biology, highlighting its mastery as an antioxidant and its therapeutic implications for promoting health and mitigating disease.

Background: According to some studies, patients with obesity seem to be more prone to have severe COVID-19 symptoms, than non-obese people. The association between obesity and an increased risk of hospitalization, critical conditions, or even death as a result of COVID-19 in Uzbekistan is currently under research. The aim of the study was to evaluate the impact of obesity on the severity and course of disease of COVID-19.

Design and methods: The design of the study is an observational cohort study. The patients were followed over 30 days, after COVID-19 disease to examine short-term outcomes. Among patients seeking medical treatment or receiving the initial medical communication in distribution centers in Tashkent, Uzbekistan, we selected 4675 consecutive patients, who had proven SARS-CoV-2 PCR-positive test results. By using a t-test to continuous data related with an increased risk of hospitalization, critical conditions, or even mortality owing to COVID-19 in Uzbekistan, we compared individuals with obesity and those who did not have obesity. Furthermore, we chose to evaluate data from databases like as PubMED, Elsevier, Cochrane, Lancet, World Obesity, Science, and World Health Organization guidelines through to the end of the еar 2021, as well as data from existing databases. In addition, we investigated a number of scientific online sites, including karger.com, Medscape, CDC.gov, and Google scholar to find the association between COVID-19 and obesity.

Despite significant advances in acute stroke management and reducing stroke mortality, there has been limited progress in preventing complications such as post-stroke epilepsy. PSE research is scattered worldwide, with varying methodologies and data collection. To address these challenges, we have established the International Post-Stroke Epilepsy Research Consortium (IPSEC). This protocol outlines a meta-analysis of individual patient data to determine outcomes in patients with post-stroke seizures and develop/validate prediction models for PSE, comparing them with existing models. The protocol also describes the creation of the International Post-Stroke Epilepsy Research Repository, which will support future collaborative research.[1]

In today's world, depending on the degree of severity, shape and size of chest deformities, chest symmetry, patient heredity, children's age and accompanying functional disorders, each has its own positive and the development of new treatment methods with adverse properties remain among the most pressing researches in pediatric surgery, large randomized clinical trials comparing existing surgical techniques are being conducted and research is being conducted on new approaches that improve the effectiveness of existing techniques.

Study of the clinical condition of the mucous membrane of the oral cavity in hyperkeratotic (typical), erosive, ulcerated, pemphigoid and scaly forms of red flat iron.

The transmission of intercourse side effects from innovation to period is an enchanting and convoluted peculiarity that has gathered sizeable interest in the areas of science, hereditary qualities, and transformative science. Sex signs, furthermore viewed as intercourse qualities or intercourse attributes, allude to the substantial and conduct credits that recognize grown-up guys from ladies in an animal variety. The transmission of these side effects from one period to the resulting is fundamental for the endurance and propagation of an animal categories, as it guarantees the continuation of conceptive cycles and the transformation of populaces to their surroundings.

This article presents the most complex problems of heart disease in the present day and the assumption of disease on the topic. This article is written using other literature.

This article presents the most complex problems of heart disease in the present day and the assumption of disease on the topic. This article is written using other literature. The new imaging technology is called HeartFlow, and it allows physicians to determine more easily if a patient needs an invasive procedure to clear blocked arteries or if a non-invasive treatment, such as medication, would work. Since 2018, more than 15,000 people around the world have used it, and it is offered in select locations throughout Banner Health.

This article talks about effective communication  and  building trust between doctor and patient relationship.

Tuberculosis or Tuberculosis is an infectious disease of bacterial etiology. The disease is considered not only medical, but also social: the most vulnerable to the tuberculosis pathogen are people with reduced immunity, those who do not eat enough, who do not follow hygiene standards, and people living in poor social conditions. The development of the disease is affected by the quality of human life. However, the entire population, regardless of age and gender, is at risk of tuberculosis.

The psycho-emotional state of 60 patients with irritable bowel syndrome was studied, as a result of which it was concluded that the emotional state is one of the contributing factors leading to the development of irritable bowel syndrome.

In this article, we are looking at traumatic papillomatosis, a complication that can occur when using improperly fitted removable dentures. This disease is characterized by the formation of papillomas on the mucous membrane of the oral cavity.

Cerebral palsy occupies a leading position among childhood neurological diseases, so this pathology requires a special approach. With this in mind, as a specific approach, the involvement of multiple specialist teams and long-term, ongoing rehabilitation will provide significant practical assistance to the patient. This rehabilitation should include clinical treatment, outpatient treatment and, of course, long-term treatment at home.

Cerebral palsy (CP) occupies a special place in the structure of morbidity and disability of the child population.[1] The term “cerebral palsy” (CP) unites a group of syndromes with different clinical manifestations that arise as a result of underdevelopment of the brain and its damage at various stages of ontogenesis and are characterized by the inability to maintain a normal posture and perform voluntary movements [5]. The success of rehabilitation depends not only on the severity damage to the central nervous system (CNS) of the child, but also from timely diagnosis, proper organization of the treatment process, starting from the first years of the child’s life. Only an analysis of the comprehensive development of a child with cerebral palsy is the basis for correct rehabilitation and prognosis. Recently, increased attention has been paid to new organizational forms in a complex multidisciplinary rehabilitation system. Among them, there is significant interest in treating children with cerebral palsy at home.

This article discusses the role of vitamin D in patients with autoimmune thyroiditis (AIT). The authors found that vitamin D levels were low in patients with AIT. In the article, the authors showed an inverse correlation between thyroid-stimulating hormone, antibodies to thyroperoxidase and thyroglobulin and vitamin D content, which indicates that vitamin D deficiency is also one of the pathogenetic links in the course of AIT.

Dry eye syndrome is a common disease characterized by rapid drying of tear fluid. Due to the decrease in the quality and quantity of tears, the surface of the cornea is not well moisturized, resulting in the appearance of microcracks and wounds. The disease causes a sharp decrease in visual acuity, so it requires treatment.

Of the large number of congenital heart defects, the leading position is occupied by congenital septal defects, among which the second place in frequency of occurrence is occupied by an isolated atrial septal defect (ASD), with a prevalence of about 7% among all congenital heart defects. The most common intercurrent pathology is pneumonia caused by hypervolemia of the small circle.  The study of the features of the course of pneumonia in young children with ASD showed that lung tissue damage was associated with hemodynamic disorders that influenced the course and outcome of pneumonia.

A comparison was made of the effectiveness of assisted reproductive technology (ART) programs in patients after surgical treatment of endometrioid ovarian cyst (EOC) and after transvaginal puncture of the EOC. The study group consisted of 47 patients who underwent the ART program after puncture of the EOC, and 48 patients who entered the ART program after surgical treatment of EOC using laparoscopic enucleation of the cyst capsule using electrocoagulation. The control group consisted of 50 patients with male factor infertility.

The oral cavity is the main gateway for infection to enter the human body. With inhaled air and food, a huge number of different microorganisms, including pathogens, are deposited on the mucous membrane. Most currently known AMPs have a broad spectrum of antimicrobial activity, acting against Gram-positive and Gram-negative bacteria, as well as yeast and some viruses. In addition, convincing evidence has been obtained that a number of AMPs have anticarcinogenic activity, as well as immunomodulators. The article examines in detail the biochemical and immunological features of antimicrobial peptides in the oral cavity. Due to the fact that oral AMPs are diverse and act on microorganisms very quickly, the likelihood of developing resistance to them is quite small. This gives hope that AMPs can be used to produce antimicrobials, resistance to which develops very slowly. Therefore, it is proposed to use AMPs with antiviral and antifungal activity in immunocompromised individuals, including AIDS patients, for the prevention and treatment of candidiasis and herpetic gingivostomatitis. The use of AMP for the prevention and treatment of gingivitis and periodontitis seems promising.     

 Qizilqum is the second largest desert in Central Asia after the Karakum desert. It is extremely complex in terms of its natural climatic environment, with sand dunes of various shapes and sizes, flat mountain ranges, plains, low depressions, shorkhok, is a geographical area consisting of a complex of gypsum fields. Geomorphologically, Kyzylkum has a very complex structure. There are hills of the Paleozoic era, which are composed of limestones, slats, and sands of various forms. The terrain characteristic of Kyzylkum is the priority of sandy areas. Saline deserts are another ecological environment characteristic of Kyzylkum, in which there are different levels of salinity and non-uniformly distributed sedimentary areas. Common grassland species occur in all soil conditions and ecological environments; Plants such as white saxovol, black saxovol, black Circassian, chogon, kandym, and izen are found in sandy deserts.

Recently, due to the increase in cases of negative impact of various anthropogenic factors on flora and fauna, there are many cases of plant poisoning among the population and livestock. The main task at the moment is to know what should be done to reduce poisoning of people and livestock from poisonous plants. In Uzbekistan, along with useful plants, there are also poisonous plants that harm humans and animals. It is important to know them and protect people and livestock from poisonous plants.